
KRAS G12C inhibitor 11
CAS No. 2158297-63-1
KRAS G12C inhibitor 11 ( —— )
产品货号. M13445 CAS No. 2158297-63-1
KRAS G12C 抑制剂 11 是一种有效的、选择性的、共价的、不可逆的 KRAS G12C 抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥11097 | 有现货 |
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50MG | ¥22518 | 有现货 |
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100MG | ¥29970 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称KRAS G12C inhibitor 11
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述KRAS G12C 抑制剂 11 是一种有效的、选择性的、共价的、不可逆的 KRAS G12C 抑制剂。
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产品描述KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM; demonstrates super proportional dose ascending oral exposure in mice with 3h target coverage at the 30 mg/kg dose; shows rapid growth inhibition and durable efficacy even after dosing was stopped, orally active.
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体外实验Kirsten Rat Sarcoma 2 Viral Oncogene Homolog (KRas) is a small GTPase and a member of the Ras family of oncogenes. KRas serves a molecular switch cycling between inactive (GDP -bound) and active (GTP -bound) states to transduce upstream cellular signals received from multiple tyrosine kinases to downstream effectors to regulate a wide variety of processes, including cellular proliferation.
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体内实验——
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同义词——
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通路MAPK/ERK Signaling
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靶点Ras
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受体Ras
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研究领域——
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适应症——
化学信息
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CAS Number2158297-63-1
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分子量551.695
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分子式C32H37N7O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCN1CCCC1COC2=NC3=C(CCN(C3)C4=CC=CC5=CC=CC=C54)C(=N2)N6CCN(C(C6)CC#N)C(=O)C=C
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化学全称2-((S)-1-acryloyl-4-(2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. U.S. Pat. Appl. Publ. (2018), US 20180072723 A1 20180315.
产品手册




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